(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide
Pipecuronium bromide
CAS: 52212-02-9
Molecular Formula: C35H62Br2N4O4
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Names and Identifiers
| Name | Pipecuronium bromide |
| Synonyms | 257-740-4 Pipecurium bromide 4,4'-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1,1-dimethylpiperazinium) Dibromide (2beta,9xi,14xi,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide (2beta,3alpha,5alpha,16beta,17beta)-3,17-Diacetoxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide (2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide 4,4'-((2Beta,3Alpha,5Alpha,16Beta,17Beta)-3,17-Bis(Acetyloxy)Androstane-2,16-Diyl)Bis(1,1-Dimethyl-Piperazinium) Dibromide |
| CAS | 52212-02-9 |
| EINECS | 257-740-4 |
| InChI | InChI=1/C35H62N4O4.2BrH/c1-24(40)42-32-21-26-9-10-27-28(35(26,4)23-31(32)37-15-19-39(7,8)20-16-37)11-12-34(3)29(27)22-30(33(34)43-25(2)41)36-13-17-38(5,6)18-14-36;;/h26-33H,9-23H2,1-8H3;2*1H/q+2;;/p-2/t26?,27-,28?,29?,30+,31+,32?,33+,34+,35+;;/m1../s1 |
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Physico-chemical Properties
| Molecular Formula | C35H62Br2N4O4 |
| Molar Mass | 762.69918 |
| Storage Condition | Room Temprature |
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Standard
Authoritative Data Verified Data
This product is 4,4 '-( 3a, 17b-dihydroxy-5a-andrographole-2b, 16B, dibasic release) BIS [1,1-dimethylpiperidine 3,17-diacetate. Pipecuronium bromide (C35H62Br2N404) should be between 97.0% and 102.0% based on anhydrous and solvent-free calculations.
Last Update：2024-01-02 23:10:35
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Trait
Authoritative Data Verified Data
- This product is white or off-white powder, odorless; It is easy to deteriorate in the air and has hygroscopicity.
- This product is dissolved in water, slightly soluble in ethanol, slightly soluble in chloroform, insoluble in ether or acetone.
specific rotation
take this product, weigh it precisely, add water to dissolve and quantitatively dilute it into a solution containing 10 mg pipecuronium bromide per 1 ml, and determine it according to law (General rule 0621), the specific rotation was 7.0 ° to 11.0 °.
Last Update：2022-01-01 13:39:55
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Differential diagnosis
Authoritative Data Verified Data
- take this product, add water to dissolve, add nitric acid to make it acidic, and add silver nitrate solution to generate light yellow precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 13:39:56
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Exam
Authoritative Data Verified Data
acidity
take this product, add water to make a solution containing 2mg per lml, according to the law (General 0631),pH value should be 5.0~7.0.
clarity and color of solution
take this product and add water to make a solution containing 2mg per lml. The solution should be clear, colorless or almost colorless.
Related substances
take lOOmg of this product, put it in a 10ml measuring flask, add the mobile phase to dissolve and dilute to the scale, shake well, as a test solution; Take appropriate amount with precision, quantitative dilution with mobile phase was made to contain O per 1 ml. 1 mg solution, as a control solution. The control solution (1 ml) was accurately weighed, placed in a 20ml measuring flask, diluted to the scale with mobile phase, and shaken to obtain a sensitivity solution. According to the chromatographic conditions under the content determination item, the sensitivity solution 20ul is injected into the human liquid chromatograph, the signal and noise of the main component peak height is injected into the human liquid chromatograph, and the chromatogram is recorded to 4 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0%), the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution. The chromatographic peaks in the chromatogram of the test solution which are smaller than the main peak area of the sensitivity solution are ignored.
residual solvent
take this product about O.lg, precision weighing, put in 10ml headspace bottle, add water lml seal, shake to dissolve, as a test solution; Respectively, take alcohol, acetone, the appropriate amount of acetonitrile and tetrahydrofuran was precisely weighed and water was added to prepare the stock solution; The appropriate amount of dichloromethane was additionally precisely weighed and N,N-dimethylmethylimine was added to prepare the stock solution; accurately take appropriate amount of each stock solution, mix, and dilute with water to make a solution containing 0.3mg of methanol, 0.5mg of acetone, 0.041mg of acetonitrile, 0.06mg of dichloromethane and 0.072mg of tetrahydrofuran per 1 ml, precision take 1 ml into 10ml headspace bottle, sealed, as a reference solution. According to the test for determination of residual solvents (General rule 0861 second method), the capillary column fixed with 6% cyanopropyl phenyl-94% dimethyl polysiloxane was used as the column, and the temperature was increased by program, the initial temperature was 40°C, and the temperature was maintained for 6 minutes, then, the temperature was increased to 180°C at a rate of 10°C per minute for 5 minutes; The detector temperature was 250°C; The inlet temperature was 200°C; And the equilibrium temperature of the headspace bottle was 80°C; the equilibration time was 30 minutes. Take the reference solution into the headspace, the separation degree of each peak should meet the requirements. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method, the residual amount of methanol, acetone, acetonitrile, dichloromethane and tetrahydrofuran shall be in accordance with the provisions.
moisture
take this product, according to the determination of moisture (General 0832 first method 1), the water content shall not exceed 10.0%.
Heavy metals
take this product 2.0g, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 20 parts per million.
Last Update：2022-01-01 13:39:57
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with decylsilane was used as the filler, and 0.02mol/L sodium heptane sulfonate solution (containing 0.5% triethylamine, adjusted to pH 3.5 with phosphoric acid)-methanol (49:51) as the mobile phase; the detection wavelength was 210nm. The number of theoretical plates shall not be less than 2000 according to the peak of pipecu bromide ammonium.
assay
take an appropriate amount of this product, precision weigh, add mobile phase to dissolve and dilute to make a solution containing about 0.4mg per 1 ml, as a test solution, take 20ul for precision, injection of human liquid chromatograph, record chromatogram; Another appropriate amount of pipecuronium bromide reference substance, the same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 13:39:58
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Category
Authoritative Data Verified Data
muscle relaxant.
Last Update：2022-01-01 13:39:58
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Storage
Authoritative Data Verified Data
sealed and stored in a cool and dry place.
Last Update：2022-01-01 13:39:58
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Purcuronium bromide for injection
Authoritative Data Verified Data
This product is a sterile freeze-dried product prepared by adding appropriate amount of pipecuonium bromide and mannitol, containing pipecuonium bromide (C35H62Br2N404) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white or off-white powder.
identification
- take the contents of 1 bottle of this product, add 5ml of water to dissolve, add nitric acid to make it acidic, and add silver nitrate test solution to generate light yellow precipitate.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- acidity take 5 bottles of this product, add 2ml of 0.9% sodium chloride solution to dissolve, combine, mix well, and measure according to law (General rule 0631). The pH value should be 5.0~7.0.
- the clarity and color of the solution take 5 bottles of this product, respectively, plus 0.9% sodium chloride solution 2ml dissolved, the solution should be clarified (General Principles 0902 The first method) colorless or almost colorless (General Principles 0901 first method).
- Related substances take this product, precision weighing, adding mobile phase to dissolve and dilute to make a solution containing about 10 mg per 1 ml, as a test solution; Take appropriate amount of precision, diluted with mobile phase to make about 0.1 mg solution, as a control solution. The control solution (1 ml) was accurately weighed, placed in a 20ml measuring flask, diluted to the scale with mobile phase, and shaken to obtain a sensitivity solution. The related substances of pipecuronium bromide were determined by this method. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (1.0%), the sum of each impurity peak area shall not be greater than 2 times (2.0%) the area of the main peak of the control solution. The chromatographic peaks in the chromatogram of the test solution which are smaller than the main peak area of the sensitivity solution are ignored. The content uniformity of
- shall be calculated based on the content of each bottle measured under the content determination item, and shall comply with the regulations (General rule 0941).
- bacterial endotoxin this product, according to the law to check (General 1143), per 1 mg of pipecuronium bromide containing endotoxin should be less than 20EU.
- the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 5.0%, first method 1).
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.02mol / L sodium heptane sulfonate (containing 0.5% triethylamine, pH adjusted to 3.5 with phosphoric acid)-methanol (49:51) as mobile phase; The detection wavelength was 210nm. The number of theoretical plates shall not be less than 2000 according to the peak of pipecu bromide ammonium.
- determination: Take 10 bottles of this product, add appropriate amount of mobile phase to dissolve, transfer to 10ml measuring flask with mobile phase quantitatively, dilute to scale with mobile phase, and shake well, as a sample solution, a 20ul injection liquid chromatograph was used for precise measurement, and the chromatogram was recorded, add appropriate amount of mobile phase to dissolve and dilute to make a solution containing about 0.4mg pipecuronium bromide per 1 ml. According to the external standard method, the content of each bottle is calculated by Peak area, and the average content of 10 bottles is obtained.
category
with pipecuonium bromide.
specification
4mg
storage
It was sealed and stored in a dry place at 2-8°C.
Last Update：2022-01-01 13:39:59
(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide - Reference Information
| дЄ≠жЦЗеРНзІ∞: | еУМеЇУжЇійУµ |
| дЄ≠жЦЗеРМдєЙиѓН: | еУМеПѓжЭЊ;4,4'-[(2ќТ,3ќС,5ќС,16ќТ,17ќТ)-3,17-еПМ(дєЩйЕ∞ж∞ІеЯЇ)йЫДзФЊзГЈ-2,16-дЇЪеЯЇ]еПМ(1,1-дЇМзФ≤еЯЇеУМеЧ™йФЪ)дЇМжЇіеМЦзЙ©;еУМеЇУжЇійУµ;йШњзЂѓ;жЇіеМЦеР°еУМиАГе∞Љ |
| иЛ±жЦЗеРНзІ∞: | Pipecuronium bromide |
| иЛ±жЦЗеРМдєЙиѓН: | pipecuronium bromide;4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide;4,4'-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetoxy)androstane-2,16-diyl]bis[1,1-dimethylpiperazinium] dibromide;PIPECURIUM BROMIDE;Pipecuronium;PIPECURINIUM BROMIDE;4пЉМ4вАЩ-[(2ќ≤пЉМ3ќ±пЉМ5ќ±пЉМ16ќ≤пЉМ17ќ≤)-3пЉМ17-Bis(acetoxy)andrc~tane-2пЉМ16-diyl]bis(1пЉМ1-dimethylpiperazinium)dibromide;Ardtm |
| CASеПЈ: | 52212-02-9 |
| еИЖе≠РеЉП: | C35H62Br2N4O4 |
| еИЖе≠РйЗП: | 762.69918 |
| EINECSеПЈ: | 257-740-4 |
| зЫЄеЕ≥з±їеИЂ: | иВМиВЙжЭЊеЉЫиНѓ;йЇїйЖЙзФ®иНѓ;иНѓзЙ©;еОЯжЦЩиНѓ |
| MolжЦЗдї∂: | 52212-02-9.mol |
| зЖФзВє | 262-264¬∞ (dec) |
| жѓФжЧЛеЕЙеЇ¶ | D25 +8.1¬∞ (c = 1 in water) |
| ж¶Вињ∞ | еУМеЇУжЇійУµ(PipecuroniumBromide)еПИеРНењЕеПѓжЭЊпЉМдЄЇеРЂжЬЙдЄ§дЄ™е≠£йУµзЪДзФЊз±їеМЦеРИзЙ©пЉМе±ЮйХњжХИйЭЮеОїжЮБжАІиВМиВЙжЭЊеЉЫз±їиНѓзЙ©гАВеУМеЇУжЇійУµдЄїи¶БдљњзФ®дЇОеЕ®иЇЂйЇїйЖЙињЗз®ЛдЄ≠иВМиВЙжЭЊеЉЫпЉМе§ЪзФ®дЇОжЧ∂йЧіеЬ®40еИЖйТЯдї•дЄКзЪДжЙЛжЬѓйЇїйЖЙпЉМзЙєеИЂжШѓеЇФзФ®дЇОењГи°АзЃ°зЦЊзЧЕжВ£иАЕеБЪењГи°АзЃ°жИЦйЭЮењГи°АзЃ°з≠ЙжЙЛжЬѓдЄ≠гАВ |
| зФЯзЙ©жіїжАІ | Pipecuronium bromide жШѓдЄАзІНжЬЙжХИзЪДйХњжХИйЭЮеОїжЮБеМЦзФЊдљУз•ЮзїПиВМиВЙйШїжїЮеЙВ (NMBA)пЉМжШѓдЄАзІНеПМе≠£йУµеМЦеРИзЙ©гАВPipecuronium bromide жШѓдЄАзІНеКЯиГљеЉЇе§ІзЪДзЂЮдЇЙжАІ nAChR жЛЃжКЧеЙВпЉМKd дЄЇ 3.06 ќЉMгАВ |
| йЭ∂зВє | nAChR |
| дљУе§Цз†Фз©∂ | Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium. |
| дљУеЖЕз†Фз©∂ | The average ED 95 is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3√Ч ED 95 , and anaphylaxis does not appear to be a problem. Carboxymethylated ќ≥-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment. |
| еМЦе≠¶жАІиі® | дїОдЇМж∞ѓзФ≤зГЈ?дЄЩйЕЃзїУжЩ∂пЉМзЖФзВє262-264вДГ(еИЖиІ£)гАВ[ќ±] D23+8.1¬∞(C=1пЉМж∞і)гАВжА•жАІжѓТжАІLD50е∞ПйЉ†пЉМе§ІйЉ†(mg/kg)пЉЪ29.7пЉМ172.6йЭЩиДЙж≥®е∞ДпЉЫ70.6пЉМ449.6иЕєиЕФж≥®е∞ДгАВ |
| зФ®йАФ | йЭЮеОїжЮБеМЦиВМиВЙжЭЊеЉЫиНѓпЉМдЄНеРМзЪДеЙВйЗПпЉМеПѓдЇІзФЯдЄНеРМзЪДжХИжЮЬеТМжМБзї≠жЧ∂йЧігАВдЄЇдЄАеЃЙеЕ®жЬЙжХИзЪДиНѓзЙ©гАВзФ®дЇОж∞ФзЃ°жПТзЃ°гАБж®™зЇєиВМжЭЊеЉЫпЉМињШеПѓзФ®дЇОдЇЇеЈ•еСЉеРЄжЧ∂зЪДдЄАиИђйЇїйЖЙгАВ |
| зФЯдЇІжЦєж≥Х | 5ќ±-йЫДзФЊ-2-зГѓ-17-йЕЃеЬ®з°ЂйЕЄеВђеМЦдЄЛпЉМеТМдєЩйЕЄеЉВдЄЩзГѓйЕѓеПНеЇФпЉМеЊЧеМЦеРИзЙ©(I)пЉМжФ∂зОЗ80%пЉМзЖФзВє96~98вДГгАВ90gеМЦеРИзЙ©(I)жЇ∂дЇО500mlиЛѓдЄ≠пЉМеЬ®еЖЈеНіеТМжРЕжЛМдЄЛпЉМдЇО1hеЖЕеК†еЕ•92gињЗиЛѓзФ≤йЕЄеЬ®1000mlиЛѓдЄ≠зЪДжЇ∂ж∂≤пЉМеЬ®еЃ§жЄ©дЄЛжФЊзљЃ5hгАВеПНеЇФж∂≤зФ®еЖ∞еЖЈеНіињЗзЪДж∞¢ж∞ІеМЦйТ†жЇ∂ж∂≤жіЧпЉМзД∂еРОж∞іжіЧпЉМжЧ†ж∞із°ЂйЕЄйХБеє≤зЗ•гАВеЗПеОЛжµУзЉ©пЉМеЙ©дљЩзЙ©зФ®дєЩйЖЪйЗНзїУжЩ∂пЉМеЊЧ80gеМЦеРИзЙ©(вЕ°)пЉМжФ∂зОЗ81%пЉМзЖФзВє182пљЮ184вДГгАВ20gеМЦеРИзЙ©(вЕ°)жЇ∂дЇО100ml N-зФ≤еЯЇеУМеЧ™еТМ30mlж∞ізЪДжЈЈеРИж∂≤пЉМеЬ®ж∞Ѓж∞ФдЄ≠еЫЮжµБ70hгАВеЗПеОЛиТЄеЗЇињЗйЗПзЪДN-зФ≤еЯЇеУМеЧ™пЉМеЙ©дљЩзЙ©еТМ2еАНйЗПзЪДдєЩиЕИжЈЈеРИпЉМж≤ЄиЕЊеЫЮжµБжХ∞еИЖйТЯгАВеЖЈиЗ≥0вДГпЉМињЗжї§жЮРеЗЇзЪДзЩљиЙ≤зїУжЩ∂пЉМзЬЯз©Їеє≤зЗ•иЗ≥жБТйЗНпЉМеЊЧ19gеМЦеРИзЙ©(вЕ¢)пЉМжФ∂зОЗ63%пЉМзЖФзВє199пљЮ201вДГгАВ10.6gеМЦеРИзЙ©(вЕ¢)жЇ∂дЇО50mlеЫЫж∞¢еСЛеЦГеТМ50mlзФ≤йЖЗзЪДжЈЈеРИж∂≤пЉМеК†еЕ•9gињЗйЗПзЪДз°Љж∞¢еМЦйТ†пЉМжРЕжЛМ6hгАВеЗПеОЛиТЄеЗЇжЇ∂еЙВпЉМеЙ©дљЩзЙ©жЇ∂дЇОж∞ѓдїњгАВеЕИзФ®2%ж∞¢ж∞ІеМЦйТ†жЇ∂ж∂≤жіЧпЉМзД∂еРОзФ®ж∞іжіЧгАВеє≤зЗ•еРОиТЄеЗЇжЇ∂еЙВпЉМеЙ©дљЩзЙ©зФ®ж∞ѓдїњеТМдЄЩйЕЃжЈЈеРИж∂≤йЗНзїУжЩ∂пЉМеЊЧ9.3gеМЦеРИзЙ©(вЕ£)пЉМжФ∂зОЗ91%пЉМзЖФзВє264пљЮ267вДГгАВ5.8gеМЦеРИзЙ©(вЕ£)жЇ∂дЇО20mlдєЩйЕЄйЕРеТМ5mlдєЩйЕЄзЪДжЈЈеРИж∂≤пЉМеК†еЕ•0.5gж∞ѓеМЦйФМпЉМеЬ®еЃ§жЄ©дЄЛжРЕжЛМ3hгАВеПНеЇФж∂≤еАЊдЇЇ250mlж∞іпЉМдЇО0вДГжФЊзљЃгАВињЗжї§еЗЇж≤ЙжЈАпЉМжЇ∂дЇОдєЩйЖЪпЉМзФ®ж∞іжіЧиЗ≥дЄ≠жАІгАВиТЄеОїжЇ∂еЙВпЉМеЖНзФ®ж≠£еЈ±зГЈйЗНзїУжЩ∂пЉМеЊЧ5gеМЦеРИзЙ©(V)пЉМжФ∂зОЗ71%пЉМзЖФзВє128пљЮ130вДГгАВ37.4gеМЦеРИзЙ©(V)еТМ16gжЇізФ≤зГЈжЇ∂дЇО1300mlдЄЩйЕЃпЉМеЬ®еЃ§жЄ©дЄЛдњЭжМБ30hгАВињЗжї§жЮРеЗЇзЪДзїУжЩ∂пЉМзФ®дЇМж∞ѓзФ≤зГЈеТМдЄЩйЕЃзЪДжЈЈеРИж∂≤жЭ•жПРзЇѓпЉМеЊЧ48gеУМеЇУжЇійУµпЉМжФ∂зОЗ92%пЉМзЖФзВє262пљЮ264вДГ(еИЖиІ£)гАВжЬАеРОдЄАж≠•еПНеЇФе¶ВдЄЛгАВ4gеМЦеРИзЙ©(V)жЇ∂дЇО40mlдЇМж∞ѓзФ≤зГЈеТМ20mlз°ЭеЯЇзФ≤зГЈзЪДжЈЈеРИж∂≤дЄ≠пЉМеК†еЕ•9mlжЇізФ≤зГЈгАВеЬ®еОЛеКЫзЃ°дЄ≠дЇОеЃ§жЄ©дЄЛжФЊзљЃ2dгАВињЗжї§йЩ§еОїдЄЙзФ≤еЯЇеМЦзЪДжЇіеМЦзЙ©еЙѓдЇІзЙ©гАВжї§ж∂≤зФ®дєЩйЖЪз®АйЗКпЉМињЗжї§ељ¢жИРзЪДеЫЇдљУпЉМзФ®дЇМж∞ѓзФ≤зГЈеТМдєЩйЖЪжЈЈеРИж∂≤йЗНзїУжЩ∂пЉМеЊЧеУМеЇУжЇійУµгАВ |
| жѓТжАІ | LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (K√°rp√°ti, Biro) |
| дЄКжЄЄеОЯжЦЩ | еЫЫж∞¢еСЛеЦГ-->дЄЙж∞ѓзФ≤зГЈ-->жЧ†ж∞із°ЂйЕЄйХБ-->ж≠£еЈ±зГЈ-->з°Љж∞¢еМЦйТ†-->дЊЭжЙШзЇ¢йЬЙзі†-->дєЩйЕЄеЉВдЄЩзГѓйЕѓ-->ињЗж∞ІеМЦж∞¢иЛѓзФ≤йЕ∞-->йЫДзФЊ-2-зГѓ-17-йЕЃ |
Last Update：2024-04-09 19:05:12
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Product Name: 4,4'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)androstane-2,16-diyl)bis(1,1-dimethyl-piperazinium) dibromide Visit Supplier Webpage Request for quotation
CAS: 52212-02-9
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 52212-02-9
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